Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to Man
نویسندگان
چکیده
Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits.
منابع مشابه
A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans.
A temperature-sensitive mutation was obtained in Med6p, a component of the mediator complex from the yeast Saccharomyces cerevisiae. The mediator complex has been shown to enable transcriptional activation in vitro. This mutation in Med6p abolished activation of transcription from four of five inducible promoters tested in vivo. There was no effect, however, on uninduced transcription, transcri...
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ورودعنوان ژورنال:
- Cell
دوره 110 شماره
صفحات -
تاریخ انتشار 2002